2006;30(5):421-425. Am J Cardiol. BMC Cardiovasc Disord. View abstract. L-Carnosine - Nootropics Expert For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Curr Med Res Opin 2004;20:1377-84. Common causes of insomnia include stress, an irregular sleep schedule, poor sleeping habits, mental health disorders like anxiety and depression, physical illnesses and pain, medications . Pediatrics 1998;101:E9 (abstract). View abstract. You may report side effects to FDA at 1-800-FDA-1088. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. View abstract. What Are the Health Benefits of Acetyl-L-Carnitine Long term side effects of high dose carnitine use are not fully known. Speak with a healthcare provider to find out what dose might be best for a specific condition. 1-1-2010;84(1):52-58. L-Carnitine Supplement Side Effects. Wang, Y. X., Yang, S. W., Qu, C. B., Huo, H. X., Li, W., Li, J. D., Chang, X. L., and Cai, G. Z. View abstract. View abstract. A., Hatfield, D. L., Vingren, J. L., Quann, E. E., Anderson, J. M., Maresh, C. M., and Kraemer, W. J. Available for Android and iOS devices. 2008;(2):CD003917. View abstract. View abstract. Thomas, S., Fischer, F. P., Mettang, T., Pauli-Magnus, C., Weber, J., and Kuhlmann, U. Carnitine deficiency during valproic acid treatment. J Perinat Med 1995;23:477-85. L-CARNITINE - Uses, Side Effects, and More - WebMD Reversal of haemodialysis induced hypertriacylglycerolemia by L-carnitine. A. L-carnitine seems to decrease how well thyroid hormone works in the body. View abstract. It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. Vicari E, La Vignera S, Calogero AE. Adefovir dipivoxil. Corbucci, G. G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. Physiologie. View abstract. Effect of L-carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis. Fulgente T, Onofrj M Del Re ML et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Harper, P., Elwin, C. E., and Cederblad, G. Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects. Colon-Soto, M., Peredo, R. A., and Vila, L. M. Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine. View abstract. Several natural foods and beverages have been shown to increase metabolism and promote fat loss. Int J Clin Pharmacol.Ther Toxicol. L-carnitine is best known as a fat burner, but the overall research is mixed. Arq Bras.Endocrinol.Metabol. What time of day is best to take L-carnitine? [Updated!] View abstract. Available at: https://www.fda.gov/orphan/designat/alldes.rtf. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Oncologist. View abstract. Ren Fail. Chazot, C., Blanc, C., Hurot, J. M., Charra, B., Jean, G., and Laurent, G. Nutritional effects of carnitine supplementation in hemodialysis patients. View abstract. View abstract. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. If you happen to feel nausea, next time just take this supplement with food or take a lesser dose. View abstract. Int J Curr Res Acad Rev 2015;3:469-76. Other drugs may interact with levocarnitine, including prescription and over-the-counter medicines, vitamins, and herbal products. BJU.Int. View abstract. Bernard, A., Rigault, C., Mazue, F., Le, Borgne F., and Demarquoy, J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. High levels of TMAO are linked to an increased risk of atherosclerosis a disease which clogs your arteries (59, 60). View abstract. Z., Wang, L. X., Liu, H. Z., Qi, X. W., Wang, X. H., and Ren, H. Z. L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction. The effects of L-carnitine on human stamina. This includes older adults and people who rarely or never eat meat and fish. Kubota K, Uojima H, Shao X, et al. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. View abstract. View abstract. Lee, P. J., Harrison, E. L., Jones, M. G., Jones, S., Leonard, J. V., and Chalmers, R. A. L-carnitine and exercise tolerance in medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency: a pilot study. Guarnieri, G. F., Ranieri, F., Toigo, G., Vasile, A., Ciman, M., Rizzoli, V., Moracchiello, M., and Campanacci, L. Lipid-lowering effect of carnitine in chronically uremic patients treated with maintenance hemodialysis. View abstract. Answer: Supplements including melatonin, tart cherry juice extract, L-tryptophan and 5-HTP, L-theanine, CBD (cannabidiol), ashwagandha, glycine, saffron, valerian, and possibly magnesium or Prevagen may, to varying degrees, improve sleep. View abstract. Neurologia 2007;22(5):329-332. J Nephrol. View abstract. Effects of L-carnitine supplemented total parenteral nutrition on lipid and energy metabolism in postoperative stress. View abstract. A., Gupta, A., Vajifdar, B. U., and Lokhandwala, Y. Y. L-carnitine moderately improves the exercise tolerance in chronic stable angina. If you do not have a dose-measuring device, ask your pharmacist for one. Exp.Physiol 2008;93(10):1139-1146. L-Carnitine for Thyroid Fatigue. Call your doctor at once if you have: a seizure (convulsions). View abstract. 2005-2023 Healthline Media a Red Ventures Company. J Int.Soc.Sports Nutr. You may report them to the FDA. Drugs Aging 2006;23(3):263-270. Carnosine is found throughout your body. Propionyl-L-carnitine is safe for most people when taken by mouth or given intravenously by a healthcare professional. Drugs Exp Clin Res 1991;17:225-35. Effects of propionyl-L-carnitine on peripheral arterial obliterative disease of the lower limbs: a double-blind clinical trial. Pichard, C., Roulet, M., Rossle, C., Chiolero, R., Schutz, Y., Temler, E., Boumghar, M., Schindler, C., Zurlo, F., Jequier, E., and . Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. Muscle carnitine deficiency in patients using valproic acid. View abstract. View abstract. 2010;37(12):2353-2354. Trk Kardiyol Dern Ars -Arch Turk Soc Cardiol. Foods That Cause Insomnia: 10 Foods to Avoid - Verywell Health Nephron 1984;38(2):120-124. To make sure L-Carnitine is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests. 2009;41(11):840-845. PLoS.One. 2010;32(8):669-672. View abstract. Nutrients 2020;12(11):3371. View abstract. Palazzuoli, V., Mondillo, S., Faglia, S., D'Aprile, N., Camporeale, A., and Gennari, C. [The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy]. 2004;34(6):615-623. If you have had a seizure, don't take L-carnitine. Korean J Gastroenterol. Gynecol Endocrinol 2019;35(8):701-5. doi: 10.1080/09513590.2019.1576622. Clin Chim Acta 1982;122:369-75. View abstract. Arch Neurol 1992;49:1137-41. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. View abstract. A randomized clinical trial. Best, Proven Brain Supplements (detailed guide) | Be Brain Fit A., Ghaith, O., Medhat, T., George, S. K., and Elshafey, E. M. Is there a role for oral L-carnitine therapy in anemia and cardiac dysfunction management in Egyptian patients on maintenance hemodialysis? L-carnitine improves glucose disposal in type 2 diabetic patients. 2010;5(12):e14433. View abstract. Intravenous dl-carnitine fails to increase the double-product during atrial pacing in patients with effort angina. Fornasini, G., Upton, R. N., and Evans, A. M. A pharmacokinetic model for L-carnitine in patients receiving haemodialysis. Nutrients 2021;13(10):3432. View abstract. There are few negative side effects from this supplement at reasonable doses. Campos Y, Arenas J. Hypertension 2009;54(3):567-574. Both humans and mice naturally produce acetyl L-carnitine under normal conditions, but studies have shown that some depression-prone animals are deficient in acetyl L-carnitine. Rizos I. View abstract. L-Carnitine supplementation in older women. A few people may notice mild headaches. J Nutr 2007;137(3 Suppl 2):847S-849S. View abstract. Clin Ter. View abstract. View abstract. J Nutr.Biochem. Many studies show that eating eggs regularly can improve health. Kidney Int 1999;69:93-106. 2010;66(2):127-136. BJU Int 2001;88:63-7.. View abstract. Preliminary report. Dial Transplant 1998;27:498-506. Am.J Kidney Dis 1999;34(4):678-687. View abstract. Drugs Exp Clin Res 1990;16:101-6. Interaction with zidovudine. Report of one case]. 2010;16(1):5-14. Haghighatdoost F, Jabbari M, Hariri M. The effect of L-carnitine on inflammatory mediators: a systematic review and meta-analysis of randomized clinical trials. (Cruciani et al., 2004). Int J Clin Pharmacol Res 1990;10(1-2):81-84. U.S. View abstract. Don't use CoQ10 if you're pregnant or breast-feeding without your doctor's approval. 2015;53(11):980-6. Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. J Inherit.Metab Dis 2007;30(1):5-22. Riccioni, C., Sarcinella, R., Palermo, G., Izzo, A., Liguori, M., Koverech, A., Messano, M., and Virmani, A. View abstract. View abstract. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. 2011;31(2):125-132. China Tropical Med 2007;7(5):753-754. Naito J, Ohashi H, Ohno M, et al. However, no studies have confirmed the benefits of carnitine supplements in these specific populations. Murakami K, Sugimoto T, Woo M, et al. View abstract. Fatouros, I. G., Douroudos, I., Panagoutsos, S., Pasadakis, P., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., Michailidis, Y., Jamurtas, A. El-Beshlawy, A., Youssry, I., El-Saidi, S., El, Accaoui R., Mansi, Y., Makhlouf, A., and Taher, A. Acta Chir Scand Suppl 1983;517:157-164. Cavallini, G., Ferraretti, A. P., Gianaroli, L., Biagiotti, G., and Vitali, G. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. J Inherit.Metab Dis 2007;30(5):811. PLoS One. According to this work, published online in the journal Nature Medicine, eating red meat delivers L-carnitine to bacteria that live in the human gut. Acta Cardiol. 2018 May;18(5):e191-e195. View abstract. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Sotobatake I, Noda S, Hayashi H, and et al. Kosolcharoen T, Nappi J, Peduzzi P, and et al. Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., and Mann, J. I. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. A., Servan-Schreiber, D., Panchalingam, K., and McClure, R. J. 2013;32(1):41-9. Loumbakis P, Anezinis P, Evangeliou A, and et al. Last updated on Aug 31, 2022. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Thomsen, J. H., Shug, A. L., Yap, V. U., Patel, A. K., Karras, T. J., and DeFelice, S. L. Improved pacing tolerance of the ischemic human myocardium after administration of carnitine. Brevetti G, Perna S, Sabba C, et al. Holzhauer, P. Casuistry: medical nutrition intervention with specific micronutrient and exercise therapy in pancreatic cancer. Galvano, F., Li, Volti G., Malaguarnera, M., Avitabile, T., Antic, T., Vacante, M., and Malaguarnera, M. Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus. 2009;32(1):E13-E19. View abstract. Semin Perinatol 1999;23:152-61. View abstract. Benvenga S, Ruggeri RM, Russo A, et al. Prohaska ES, Muzyk AJ, Rivelli SK. 2014 Jul 21;14:88. View abstract. J.Japanese Society Nutrition Food Sci 2007;60(5):257-264. Medically reviewed by Drugs.com on Jun 6, 2022. 2005;59(4):592-596. View abstract. Long-term treatment with L-carnitine in uremic patients undergoing chronic hemodialysis: effects on the lipid pattern. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. Weng Y, Zhang S, Huang W, Xie X, Ma Z, Fan Q. Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. 2012;7(11):1836-1842. (Tokyo) 2001;47(6):378-384. Tsoko M, Beauseigneur F, Gresti J, et al. Shingu Y, Katoh N, Ooka T, Katoh H, Wakasa S. L-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery. Muniyappa, R. Oral carnitine therapy and insulin resistance. Tejani, A. M., Wasdell, M., Spiwak, R., Rowell, G., and Nathwani, S. Carnitine for fatigue in multiple sclerosis. Rogerson, M. E., Rylance, P. B., Wilson, R., De Sousa, C., Lanigan, C., Rose, P. E., Howard, J., and Parsons, V. Carnitine and weakness in haemodialysis patients. View abstract. 2018 Oct;59(10):2360-2368. Moradi, M., Moradi, A., Alemi, M., Ahmadnia, H., Abdi, H., Ahmadi, A., and Bazargan-Hejazi, S. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. View abstract. De Ritis G, Picardo S, Brancadoro D, and et al. Interventions for treating leg ulcers in people with sickle cell disease. Is there a special pill or food out there? BMC.Neurol. Csiky, B., Nyul, Z., Toth, G., Wittmann, I., Melegh, B., Rauh, M., Rascher, W., and Sulyok, E. L-carnitine supplementation and adipokines in patients with end-stage renal disease on regular hemodialysis. Alcohol Alcohol 2010;45(5):449-455. J Androl 2012;33(4):615-623. Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study. Schmidt-Sommerfeld E, Penn D. Carnitine and total parenteral nutrition of the neonate. View abstract. Eur J Pediatr 1995;154:686-7. View abstract. Cancer Chemother Pharmacol 1999;44:170-2. Am J Dis Child 1991;145:999-1001. Electromyogr.Clin Neurophysiol. Abbasnezhad A, Choghakhori R, Kashkooli S, Alipour M, Asbaghi O, Mohammadi R. Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. View abstract. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. Your L-carnitine levels are influenced by how much youre eating and how much your body is producing. Reprod Biol Endocrinol 2018;16(1):5. View abstract. J Interferon Cytokine Res 2011;31(9):653-659. Brass, E. P., Adler, S., Sietsema, K. E., Hiatt, W. R., Orlando, A. M., and Amato, A. 2007;29(8):517-530. Plochl, E., Sperl, W., Wermuth, B., and Colombo, J. P. [Carnitine deficiency and carnitine therapy in a patient with Rett syndrome]. Int Urol Nephrol 2021;53(10):2149-2158. 2006;17(2):73-88. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Int.J Cosmet.Sci 2011;33(6):519-526. View abstract. 2013 May;19(5):576-85. Zhonghua Nan.Ke.Xue. When taken by mouth: L-carnitine is likely safe when taken for up to 12 months. View abstract. Passeri M, Cucinotta D, Bonati PA, et al. Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature. View abstract. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Diabetologia 1997;40(1):A32. Case report]. Eur.J Haematol. Bellinghieri, G., Savica, V., Mallamace, A., Di, Stefano C., Consolo, F., Spagnoli, L. G., Villaschi, S., Palmieri, G., Corsi, M., and Maccari, F. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Cochrane.Database.Syst.Rev. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. View abstract. It can cause side effects such as nausea, vomiting, stomach upset, heartburn, diarrhea, and seizures. View abstract. Yang SK, Xiao L, Song PA, Xu X, Liu FY, Sun L. Effect of L-carnitine therapy on patients in maintenance hemodialysis: a systematic review and meta-analysis. Hum Reprod Update 1996;2:87-102. New Trends Clin Neuropharmacol 1989;3(4):225-230. [Infantile encephalopathy associated with the MELAS A3243G mutation. View abstract. Medicine (Baltimore). View abstract. Mondillo, S., Faglia, S., D'Aprile, N., Mangiacotti, L., Campolo, M. A., Agricola, E., and Palazzuoli, V. [Therapy of arrhythmia induced by myocardial ischemia. Propionyl-L-Carnitine - RxList However, there were some mild side effects, including nausea and stomach discomfort (24, 58). Cochrane.Database.Syst.Rev. As stated previously, foods high in sugar and saturated fat have been associated with poor sleep quality and sleep disturbances . Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. Erbas, H., Aydogdu, N., Usta, U., and Erten, O. Can.J Public Health 2008;99(4):276-280. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. 2014 Oct;84(4):821-5. Maggi GC, Lomanto B, and Mazzola, C. Double-blind multicenter clinical trial on the efficacy of phosphocreatinine vs L-carnitine and placebo in a group of patients affected by heart disease. It can cause side effects such as stomach upset, heartburn, diarrhea, and seizures. L-Carnitine as a diet supplement in patients with type II diabetes. Liammongkolkul, S., Kuptanon, C., Wasant, P., Vatanavicharn, N., Sawangareetrakul, P., Keeratichamroen, S., Cairns, J. R. K., Srisomsap, C., and Svasti, J. View abstract. View abstract. Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial. "L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis." Xu XQ, Jing ZC, Jiang X, et al. View abstract. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M., Gandini, L., Buchetti, B., Lenti, L., Jannini, E. A., and Lenzi, A. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Research suggests that L-carnitine may aid exercise performance and treat health conditions like heart disease and type 2 diabetes. Thom H, Carter PE, Cole GF, et al. View abstract. (56-58) L-carnitine levels may be decreased in hypothyroidism, potentially due to reduced synthesis of L-carnitine while we are in a . Sheida A, Davar R, Tabibnejad N, Eftekhar M. The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial. 2019;14(6):504-514. View abstract. View abstract. Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. Nutr J. View abstract. Stefan M, Sharp M, Gheith R, et al.